Eukaryotic parasites are responsible for millions of human deaths every year due to diseases such as malaria or diarrhea. Unfortunately, the biology of most human parasites remains very poorly understood, especially those that cannot be studied in vitro or in animal models.
Our laboratory is interested in developing novel genomic approaches to study eukaryotic parasites, with a primary focus on Plasmodium vivax, an important human parasite responsible for the majority of malaria cases outside Africa. Since P. vivax cannot be continuously propagated in the laboratory, we are applying a variety of genomic assays – whole genome sequencing, high-throughput genotyping, RNA-seq, single-cell assays – to characterize its diversity and response to environmental or therapeutic stresses. We are also interested in studying the mosquito species transmitting human pathogens and are developing genomic tools to characterize the genetic diversity of mosquitoes and their vector potential. Finally, we recently expanded our studies to other eukaryotic parasites and are using novel assays to identify and characterize neglected parasites in a comprehensive manner.