SPARC (Search Procedures for Analysis of Residue Constraints)

SPARC facilitates biochemical interpretation of  sequence and structural features identified by the DARC, BPPS or SIPRIS programs. It takes two types of input:  (1) Given a set of structures for homologous proteins and a corresponding multiple sequence alignment, it computes a STARC S-score for each structure as a measure of  biological relevance. (2) Given a set of molecular dynamics simulated structures of a specific protein complex, it identifies structures exhibiting hydrogen bonds: (a) among BPPS pattern residues; (b) stably maintained between residues during the simulation; or (c) involving a specific residue pair or a specific residue and ligand.

SPARC executable (beta release)

Reference:  Neuwald, A.F. 2022. SPARC: Search Procedures for Analysis of Residue Constraints. In preparation.
Funding: the National Institutes of Health, National Institute of General Medical Sciences grant R01GM125878.