Statistical evidence for how protein molecular machines work
DARC output showing functionally relevant residues (colored sidechains) and top scoring directly coupled residue pairs (bars connecting α-carbons) characteristic of bacterial DNA clamp loader γ subunits.
Andrew Neuwald’s lab at the Institute for Genome Sciences develops and applies computational approaches to protein sequence/structural analysis. Our methods relylargelyon sequence data with results interpreted in the light of available structures and of published biochemical studies. They apply both Bayesian and frequentist statistics.